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KMID : 1144320130450020211
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감염과 화학요법
2013 Volume.45 No. 2 p.211 ~ p.216
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Depression Among HIV-infected Patients in Korea: Assessment of Clinical Significance and Risk Factors
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Song Joon-Young
Lee Jin-Soo
Seo Yu-Bin
Kim In-Seon
Noh Ji-Youn
Baek Ji-Hyeon
Cheong Hee-Jin
Kim Woo-Joo
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Abstract
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Background: With prolonged life expectancies, mental illness has emerged as a disabling disorder among people with HIV.
Materials and Methods: This study was conducted to assess the prevalence of depression and its risk factors among Korean patients with HIV infections. Eighty-two HIV-infected patients completed structured questionnaires including the Beck Depression Inventory and the State-Trait Anxiety Inventory. Subjects with depression were compared to those without depression in terms of demographics, comorbidities, CD4 T-cell count, RNA copy numbers, highly active antiretroviral therapy (HAART) regimens, and adherence. Results: The estimated depression rate was 21% (17 of 82 subjects). Comorbidities (47% vs. 20%, P = 0.01) and unemployment (65% vs. 31%, P = 0.02) were risk factors for depression. Depressive patients were more likely to be anxious (71% vs. 29%, P < 0.01), to frequently miss clinical appointments each year (P = 0.04), and to have higher cumulative time lost to follow-up per month (P <0.01) compared to non-depressive patients. Only three depressive patients were referred to neuropsychologists. Conclusions: More than 20% of the Korean HIV patients in this study suffered from depression associated with poor adherence. Considering the low level of recognition of depression by clinicians, risk factor-based active assessment is recommended to manage depression properly in HIV-infected patients.
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KEYWORD
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HIV, Acquired immunodeficiency syndrome, Depression, Anxiety
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